Sodium borohydride → HCID 67028257, compound

HRID 2048136Notes

Reaction equation

HRID 2048136 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([CH2:15][OH:16])=[CH:17][CH:18]=3)[N:10]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86631774HCID 86631774, compound

Product 1

HCID 67028257HCID 67028257, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the stirred solution 4-(6-bromo-3-phenylimidazo[1,2-a]pyridin-2-yl)benzaldehyde (0.795 mM) in 15 mL of methanol is added NaBH4 (1.5 eq) at 0° C. and the reaction is allowed to stir at room temperature for 1 hr. The reaction is concentrated and quenched with water. The precipitated solid is filtered and dried to yield the desired product.

Workup

  1. concentrationThe reaction is concentrated
  2. customquenched with water
  3. filtrationThe precipitated solid is filtered
  4. customdried

Sources & evidence

ORD record
ord-17ac05a9e61b4f0089ece533ca9ac0e9
Source dataset
uspto-grants-2013_11
Patent number
US08592591B2

Reaction notes

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