HCID 178418582, compound → HCID 178487827, compound

HRID 2048147Notes

Reaction equation

HRID 2048147 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH2:17][N:18]4[CH2:23][CH2:22][CH:21]([C:24]5[N:28]=[C:27]([C:29]6[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=6)[NH:26][N:25]=5)[CH2:20][CH2:19]4)=[CH:13][CH:12]=3)[N:10]=2)[N:7]=1.[O:41]([CH3:43])[Na]>CO>[CH3:43][O:41][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH2:17][N:18]4[CH2:23][CH2:22][CH:21]([C:24]5[N:28]=[C:27]([C:29]6[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=6)[NH:26][N:25]=5)[CH2:20][CH2:19]4)=[CH:13][CH:12]=3)[N:10]=2)[N:7]=1

Participants

4

Reactant 2

HCID 178418582HCID 178418582, compoundHCID 178477884HCID 178477884, compound

Product 1

HCID 178487827HCID 178487827, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of example 31 (0.2 g, 0.366 mM) in 15 mL of methanol is added NaOCH3 (10 eq.) and the reaction mixture is refluxed for 6 h. The reaction mixture is concentrated and quenched with water. The resulting solid is filtered and dried to obtain the desired compound.

Workup

  1. temperaturethe reaction mixture is refluxed for 6 h
  2. concentrationThe reaction mixture is concentrated
  3. customquenched with water
  4. filtrationThe resulting solid is filtered
  5. customdried

Sources & evidence

ORD record
ord-6bddd2612b144296a3efc66e7b08500a
Source dataset
uspto-grants-2013_11
Patent number
US08592591B2

Reaction notes

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