Dimethyl Sulfoxide → 5-Chloro-N-((1-(4-(3-oxomorpholino)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide

HRID 204892Notes

Reaction equation

HRID 204892 reaction equation
[CH3:47][S:48]([CH3:49])=[O:50].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][CH2:10][c:11]2[n:12][cH:13][n:14](-[c:16]3[cH:17][cH:18][c:19]([I:22])[cH:20][cH:21]3)[cH:15]2)[s:6]1.[Cu:51][I:52].[K+:41].[K+:42].[O-:43][C:44]([O-:45])=[O:46].[O:23]1[CH2:24][C:25](=[O:29])[NH:26][CH2:27][CH2:28]1.[OH:30][c:31]1[cH:32][cH:33][cH:34][c:35]2[c:36]1[n:37][cH:38][cH:39][cH:40]2>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][CH2:10][c:11]2[n:12][cH:13][n:14](-[c:16]3[cH:17][cH:18][c:19]([N:26]4[C:25](=[O:29])[CH2:24][O:23][CH2:28][CH2:27]4)[cH:20][cH:21]3)[cH:15]2)[s:6]1

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 19238-HydroxyquinolineHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 669533-MorpholinoneHCID 249868975-Chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide

Product 1

HCID 160619525-Chloro-N-((1-(4-(3-oxomorpholino)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-12e45e6a1e8b4d0a918bb9e4c93c3722
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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