Ciproximida → HCID 21417233, compound

HRID 2049002Notes

Reaction equation

[CH2:1]1[C:3]2([C:9]3C=CC(Cl)=C[CH:10]=3)C(N[C:7](=O)[CH:2]12)=O.[C:16]([OH:23])(=[O:22])/[CH:17]=[CH:18]/[C:19]([OH:21])=[O:20]>>[C:16]([OH:23])(=[O:22])/[CH:17]=[CH:18]/[C:19]([OH:21])=[O:20].[CH3:7][CH2:2][CH2:1][CH2:3][CH2:9][CH3:10]

Participants

Reactant 2

HCID 27361Ciproximida

HCID 444972Fumaric Acid

Product 1

HCID 21417233HCID 21417233, compound

Procedure

In the above manner 1-(p-chlorophenyl)-1,2-cyclopropanedicarboximide (U.S. Pat. No. 3,344,026) is converted to N-[4,4-bis(p-fluoropphenyl)butyl] -1-(p-chlorophenyl)-1,2-cyclopropanedicarboximide, m.p. 98°-99° C. This compound is reduced as in Example 27 and the base is combined with fumaric acid to give 3-(4,4-bis(p-fluorophenyl)butyl]-1-(p-chlorophenyl)-3-azabicyclo]3.1.0]hexane fumarate as colorless crystals, m.p. 152°-154° C.

Sources & evidence

ORD record: ord-ea7b9006e44744d4922c511c7027ac10
Source dataset: uspto-grants-1980_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04196120

Reaction notes

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