Ciproximida → HCID 21417233, compound

Participants

Reaction Steps

In the above manner 1-(p-chlorophenyl)-1,2-cyclopropanedicarboximide (U.S. Pat. No. 3,344,026) is converted to N-[4,4-bis(p-fluoropphenyl)butyl] -1-(p-chlorophenyl)-1,2-cyclopropanedicarboximide, m.p. 98°-99° C. This compound is reduced as in Example 27 and the base is combined with fumaric acid to give 3-(4,4-bis(p-fluorophenyl)butyl]-1-(p-chlorophenyl)-3-azabicyclo]3.1.0]hexane fumarate as colorless crystals, m.p. 152°-154° C.

Provenance & Evidence