Hydrochloric Acid → Tris(aminomethyl)phosphine oxide trihydrochloride

HRID 2049007Notes

Reaction equation

HRID 2049007 reaction equation
[N:1]12C[N:5]3[CH2:6][P:7](=[O:10])([CH2:9][N:3](C3)C1)[CH2:8]2.[ClH:12]>O>[ClH:12].[ClH:12].[ClH:12].[NH2:5][CH2:6][P:7](=[O:10])([CH2:9][NH2:3])[CH2:8][NH2:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1430621,3,5-Triaza-7-phosphaadamantane 7-oxide

Product 1

HCID 12660547Tris(aminomethyl)phosphine oxide trihydrochlorideYield 60%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Following the procedure outline in Example 6, the 1,3,5-triaza-7-phosphaadamantane-7-oxide (7.92 g, 0.04 mol) was hydrolyzed with a solution of 22 g (0.22 mol) of 37.7% hydrochloric acid and 80 g of water, giving, after workup, 5.9 g (60% yield) of tris(aminomethyl)phosphine oxide trihydrochloride, dec. 239° C. without melting.

Workup

  1. customgiving

Sources & evidence

ORD record
ord-7f7687a32ad243e485ef272f106fa321
Source dataset
uspto-grants-1980_04
Patent number
US04196149

Reaction notes

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