Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 20345852 | HCID 20345852 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178513086 | HCID 178513086 | — |
Reaction Steps
Guanidine hydrochloride (3.34 g., 0.035 mole) is added to a solution of sodium methoxide (1.67 g., 0.032 mole) in methanol (20 ml.) with stirring at 25° C. After 15 minutes, methyl 3,5-diamino-6-trifluoromethylthio-2-pyrazinoate (1.85 g., 0.007 mole) is added, and the mixture is heated on a steam bath for 15 min. Crushed ice--H2O (20 ml.) is added to the reaction mixture to precipitate 390 mg. of N-amidino-3,5-diamino-6-trifluoromethylthio-2-pyrazinecarboxamide, m.p. 195° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04196292 |
|---|
| Source dataset | uspto-grants-1980_04 |
|---|
| ORD ID | ord-63ab033c74f348989514258be4d73ca9 |
|---|
| Source note | uspto-grants-1980_04 |
|---|
