Water → HCID 178513086, compound

HRID 2049120Notes

Reaction equation

HRID 2049120 reaction equation
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].C[O-].[Na+].[NH2:9][C:10]1[C:11]([C:22]([O:24]C)=[O:23])=[N:12][C:13]([S:17][C:18]([F:21])([F:20])[F:19])=[C:14]([NH2:16])[N:15]=1.O>CO>[OH2:23].[C:3]([NH:5][C:22]([C:11]1[C:10]([NH2:9])=[N:15][C:14]([NH2:16])=[C:13]([S:17][C:18]([F:19])([F:20])[F:21])[N:12]=1)=[O:24])(=[NH:2])[NH2:4]

Participants

6

Reactant 4

HCID 962WaterHCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 20345852HCID 20345852, compound

Product 1

HCID 178513086HCID 178513086, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

Guanidine hydrochloride (3.34 g., 0.035 mole) is added to a solution of sodium methoxide (1.67 g., 0.032 mole) in methanol (20 ml.) with stirring at 25° C. After 15 minutes, methyl 3,5-diamino-6-trifluoromethylthio-2-pyrazinoate (1.85 g., 0.007 mole) is added, and the mixture is heated on a steam bath for 15 min. Crushed ice--H2O (20 ml.) is added to the reaction mixture to precipitate 390 mg. of N-amidino-3,5-diamino-6-trifluoromethylthio-2-pyrazinecarboxamide, m.p. 195° C.

Workup

  1. temperaturethe mixture is heated on a steam bath for 15 min
  2. customto precipitate 390 mg

Sources & evidence

ORD record
ord-63ab033c74f348989514258be4d73ca9
Source dataset
uspto-grants-1980_04
Patent number
US04196292

Reaction notes

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