Dichloroacetyl chloride → HCID 12851517, compound

HRID 2049180Notes

Reaction equation

HRID 2049180 reaction equation
C(N(CC)CC)C.[Cl:8][CH:9]([Cl:13])[C:10](Cl)=[O:11].[Cl:14][C:15]([Cl:22])([Cl:21])[CH:16]1[NH:20][CH2:19][CH2:18][S:17]1>CCOCC>[Cl:14][C:15]([Cl:22])([Cl:21])[CH:16]1[N:20]([C:10](=[O:11])[CH:9]([Cl:13])[Cl:8])[CH2:19][CH2:18][S:17]1

Participants

5

Reactant 3

HCID 6593Dichloroacetyl chlorideHCID 8471TriethylamineHCID 2113432-(Trichloromethyl)-1,3-thiazolidine

Product 1

HCID 12851517HCID 12851517, compoundYield 83.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

40 g of triethylamine (0.4 mole), then 43 g of dichloroacetyl chloride (0.3 mole) are added successively, while maintaining the temperature of the reaction mixture at about 0° C. to 41 g of 2-trichloromethyl-1,3-thiazolidine (0.2 mole), dissolved in 300 ml of ether. After the removal of the triethylamine hydrochloride formed in the reaction and washing the organic phase with water, the organic layer is concentrated by stripping part of the ether. By crystallization and filtration, 53 g (yield 82%) of 2-trichloromethyl-3-dichloroacetyl-1,3-thiazolidine of melting point 124° C. is obtained.

Workup

  1. customAfter the removal of the triethylamine hydrochloride
  2. customformed in the reaction
  3. washwashing the organic phase with water
  4. concentrationthe organic layer is concentrated

Sources & evidence

ORD record
ord-4666f17f9858472dabfe5927c37920cf
Source dataset
uspto-grants-1980_04
Patent number
US04197110

Reaction notes

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