反应详情

温度

0 °C

α-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid (0.1 mole), is dissolved in water, the pH of which is about 8. This solution is cooled to 0° C. and benzyl chloroformate (0.1 mole) is added dropwise along with 1N sodium hydroxide so as to maintain the pH at 8 to 9. After the addition, the solution is stirred at 0° C. for 30 minutes and 30 minutes at room temperature. The solution is washed with ethyl ether and then acidified with hydrochloric acid. The title compound is then recovered from the aqueous solution.

1. temperatureto maintain the pH at 8 to 9
2. additionAfter the addition
3. washThe solution is washed with ethyl ether
4. customThe title compound is then recovered from the aqueous solution