Benzyl chloroformate → alpha-(Benzyloxycarbonyl)amino-4-hydroxy-3-(methoxymethyl)-benzeneacetic acid

HRID 2049226노트

반응식

HRID 2049226 반응식
[NH2:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([CH2:13][O:14][CH3:15])[CH:7]=1)[C:3]([OH:5])=[O:4].Cl[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18].[OH-].[Na+]>O>[CH2:20]([O:19][C:17]([NH:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([CH2:13][O:14][CH3:15])[CH:7]=1)[C:3]([OH:5])=[O:4])=[O:18])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

5

반응물 3

HCID 10387Benzyl chloroformateHCID 14798Sodium HydroxideHCID 23329768alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid

생성물 1

HCID 20344766alpha-(Benzyloxycarbonyl)amino-4-hydroxy-3-(methoxymethyl)-benzeneacetic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

α-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid (0.1 mole), is dissolved in water, the pH of which is about 8. This solution is cooled to 0° C. and benzyl chloroformate (0.1 mole) is added dropwise along with 1N sodium hydroxide so as to maintain the pH at 8 to 9. After the addition, the solution is stirred at 0° C. for 30 minutes and 30 minutes at room temperature. The solution is washed with ethyl ether and then acidified with hydrochloric acid. The title compound is then recovered from the aqueous solution.

후처리

  1. temperatureto maintain the pH at 8 to 9
  2. additionAfter the addition
  3. washThe solution is washed with ethyl ether
  4. customThe title compound is then recovered from the aqueous solution

출처 및 근거

ORD 기록
ord-970ef02ea6f045bcacf0c884ff8a1314
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04197240

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