HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → Hexahydro-3-(3-methoxyphenyl)-2H-azepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(3-hydroxyphenyl)hexahydro-2H-azepin-2-one | HCID 12665523 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Hexahydro-3-(3-methoxyphenyl)-2H-azepin-2-one | HCID 12875111 | — |
Reaction Steps
A suspension of hexahydro-3-(3-hydroxyphenyl)-2H-azepin-2-one (4.1 g), anhydrous potassium carbonate (5.6 g) and dimethyl sulphate (2.52 g) was heated under reflux with stirring in acetone (50 ml). After cooling the solution was filtered and evaporated to dryness under reduced pressure. The product was recrystallised from diisopropyl ether/ethyl acetate affording the title compound, identical to that obtained by the method of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04197241 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-14d09d2b2e5748939466a7a19a4db96f |
| Source note | uspto-grants-1980_04 |