反应详情

A suspension of hexahydro-3-(3-hydroxyphenyl)-2H-azepin-2-one (4.1 g), anhydrous potassium carbonate (5.6 g) and dimethyl sulphate (2.52 g) was heated under reflux with stirring in acetone (50 ml). After cooling the solution was filtered and evaporated to dryness under reduced pressure. The product was recrystallised from diisopropyl ether/ethyl acetate affording the title compound, identical to that obtained by the method of Example 1.

1. temperaturewas heated
2. temperatureunder reflux
3. temperatureAfter cooling the solution
4. filtrationwas filtered
5. customevaporated to dryness under reduced pressure
6. customThe product was recrystallised from diisopropyl ether/ethyl acetate affording the title compound
7. customidentical to that obtained by the method of Example 1