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HRID2049470

反应详情

EQUATION

反应方程式

HRID 2049470 的结构方程式

REACTANTS

反应物

3
结构：c1ccncc1
HCID1049

Pyridine

C5H5N

结构：[Cl-].[NH3+]O
HCID21645

Hydroxylamine hydrochloride

H4ClNO

结构：CC(=O)C1=CC[C@H]2[C@@H]3CC[C@H]4CC=CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID12796452

未命名化合物

PRODUCTS

生成物

1
结构：CC(=NO)C1=CC[C@H]2[C@@H]3CC[C@H]4CC=CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID86736925

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A mixture of 5α-pregna-2,16-diene-11,20-dione (60 g), hydroxylammonium chloride (21 g) and anhydrous pyridine (240 ml) was left to stand at room temperature overnight before diluting with ice and water. The precipitate obtained was collected by filtration, washed with water and dried in vacuo at 80° (62 g.). Crystallisation from ethyl acetate afforded the title compound, m.p. 168°-182°, [α]D +137°.

WORKUP

后处理

  1. waitwas left
  2. customThe precipitate obtained
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried in vacuo at 80° (62 g.)
  6. customCrystallisation from ethyl acetate