Dimethylamine → HCID 178484606, compound

HRID 2049564Notes

Reaction equation

HRID 2049564 reaction equation
[SH:1][C:2]1[N:6]([CH2:7][C:8]([O:10]CC)=O)[N:5]=[N:4][N:3]=1.[CH3:13][NH:14][CH3:15]>C(O)C>[CH3:13][N:14]([CH3:15])[C:8](=[O:10])[CH2:7][N:6]1[C:2]([SH:1])=[N:3][N:4]=[N:5]1

Participants

4

Reactant 2

HCID 674Dimethylamine2×HCID 178472662HCID 178472662, compound

Product 1

HCID 178484606HCID 178484606, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Procedure

Ethyl 5-mercapto-1H-tetrazol-1-ylacetate (1.5 g) in ethanol (10 ml) and 33% dimethylamine in ethanol (6 ml) were mixed and set aside for seven days. Further 33% dimethylamine in ethanol (6 ml) was added and the solution left for 7 more days then evaporated to dryness in vacuo. The residue was dissolved in water (50 ml), adjusted to pH 1.8, and concentrated to ca 20 ml in vacuo. The solution was cooled in ice and the crystalline product collected, 0.94 g (63.0%), m.p. 204°-205°; ε [(CD3)2CO] 3.02 and 3.28 (6H, 2×s --N(CH3)2), 5.35 (2H,s, --CH2CO--), 7.7 (1H,bs, --SH). Found: C, 32.21; H, 5.01; N, 37.63; S, 16.99. C5H9N5OS requires: C, 32.08; H, 4.85; N, 37.41; S, 17.13%.

Workup

  1. waitthe solution left for 7 more days
  2. customthen evaporated to dryness in vacuo
  3. dissolutionThe residue was dissolved in water (50 ml)
  4. concentrationconcentrated to ca 20 ml in vacuo
  5. temperatureThe solution was cooled in ice
  6. customthe crystalline product collected

Sources & evidence

ORD record
ord-9a56cc28ce57432ba518ed6449a5f68d
Source dataset
uspto-grants-1980_04
Patent number
US04198406

Reaction notes

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