Water → HCID 20344091, compound

HRID 2049632Notes

Reaction equation

HRID 2049632 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]#N.[OH-:18].[K+].[OH2:20]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]([OH:20])=[O:18]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 20344097HCID 20344097, compound

Product 1

HCID 20344091HCID 20344091, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(3-Fluorophenoxy)benzeneacetonitrile (23 g.), dissolved in 80 ml of ethanol, was heated to reflux for 2 hours with a solution of 20 g. potassium hydroxide in 40 ml of water. The ethanol was evaporated, the residue taken up in water, extracted with ether and acidified to give the title compound, m.p. 81°-84°. ##STR14##

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 2 hours with a solution of 20 g
  3. customThe ethanol was evaporated
  4. extractionextracted with ether

Sources & evidence

ORD record
ord-edc0a06b9dde40c99ba4058d36da2e78
Source dataset
uspto-grants-1980_04
Patent number
US04198421

Reaction notes

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