HCID 20344091, compound → HCID 20344093, compound

HRID 2049633Notes

Reaction equation

HRID 2049633 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]([OH:15])=O>O>[F:1][C:2]1[CH:18]=[CH:17][C:16]2[C:13](=[O:15])[CH2:12][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[O:5][C:4]=2[CH:3]=1

Participants

3

Reactant 1

HCID 20344091HCID 20344091, compound

Product 1

HCID 20344093HCID 20344093, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-(3-Fluorophenoxy)benzeneacetic acid (22 g.) was added to 90 g. of polyphosphoric acid at 125°. The reaction mixture was stirred 1 hour at 125°. It was then cooled; water (300 ml) was added with stirring; a solid product was filtered and extracted with toluene several times. The combined toluene extracts were washed successively with water, dilute alkali, and water, then dried over magnesium sulfate and evaporated to yield the title compound as a solid product, which was purified upon treatment with hexane. ##STR15##

Workup

  1. customat 125°
  2. temperatureIt was then cooled
  3. stirringwith stirring
  4. filtrationa solid product was filtered
  5. extractionextracted with toluene several times
  6. washThe combined toluene extracts were washed successively with water
  7. additiondilute alkali, and water
  8. dry with materialdried over magnesium sulfate
  9. customevaporated

Sources & evidence

ORD record
ord-345b32881f654435a82c1ffd1be7e4fd
Source dataset
uspto-grants-1980_04
Patent number
US04198421

Reaction notes

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