Potassium thiocyanate → HCID 178505425, compound

HRID 2049634Notes

Reaction equation

HRID 2049634 reaction equation
Cl.[NH2:2][CH:3]1[C:9](=O)[C:8]2[CH:11]=[CH:12][C:13]([F:15])=[CH:14][C:7]=2[O:6][C:5]2[CH:16]=[CH:17][CH:18]=[CH:19][C:4]1=2.[S-:20][C:21]#[N:22].[K+]>C(O)(=O)C>[F:15][C:13]1[CH:12]=[CH:11][C:8]2[C:9]3[NH:22][C:21]([SH:20])=[N:2][C:3]=3[C:4]3[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=3[O:6][C:7]=2[CH:14]=1

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 20344094HCID 20344094, compound

Product 1

HCID 178505425HCID 178505425, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

11-Amino-7-fluorodibenz[b,f]oxepin-10(11H)-one hydrochloride (8 g) was suspended in acetic acid (120 ml); potassium thiocyanate (2.82 g) was added and the reaction mixture was heated to reflux. After 10 minutes complete solution was obtained and shortly thereafter a solid began to separate. Heating was continued for 15 minutes. After cooling, the solid product was collected by filtration, washed with water and dried to give 10-fluoro-1H-dibenzo[2,3:6,7]oxepino[4,5-d]-imidazole-2-thiol; m.p. 299°-300°. ##STR18##

Workup

  1. temperaturethe reaction mixture was heated to reflux
  2. customAfter 10 minutes complete solution was obtained
  3. customto separate
  4. temperatureHeating
  5. temperatureAfter cooling
  6. filtrationthe solid product was collected by filtration
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-2156e21584e143e89148d3cfa5660ff5
Source dataset
uspto-grants-1980_04
Patent number
US04198421

Reaction notes

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