Potassium thiocyanate → HCID 178505425, compound

Participants

Reaction Steps

11-Amino-7-fluorodibenz[b,f]oxepin-10(11H)-one hydrochloride (8 g) was suspended in acetic acid (120 ml); potassium thiocyanate (2.82 g) was added and the reaction mixture was heated to reflux. After 10 minutes complete solution was obtained and shortly thereafter a solid began to separate. Heating was continued for 15 minutes. After cooling, the solid product was collected by filtration, washed with water and dried to give 10-fluoro-1H-dibenzo[2,3:6,7]oxepino[4,5-d]-imidazole-2-thiol; m.p. 299°-300°. ##STR18##

Provenance & Evidence