HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoylacetone → (4-amino-2-methyl-5-phenyl-1H-pyrrol-3-yl)-phenylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoylacetone | HCID 7166 | — |
| Reactant | 2-Amino-2-phenylacetonitrile | HCID 40838 | — |
| Solvent | Diethylether hexane | HCID 21584099 | — |
| Product | (4-amino-2-methyl-5-phenyl-1H-pyrrol-3-yl)-phenylmethanone | HCID 3042143 | — |
Reaction Steps
Starting from 2-amino-2-phenylacetonitrile and benzoylacetone, the open-chain intermediate compound is obtained, melting at 134°-135° C. (from diethyl ether/hexane). The title compound is obtained in a 60% overall yield. M.P. 285°-290° C. (from methanol/diethyl ether). The free base melts at 203°-5° C. (from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04198502 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-37de0f06b8684a3297449ac6f88d4493 |
| Source note | uspto-grants-1980_04 |