2-Benzyl-3-chloroisoquinolin-1(2H)-one → 2-Benzyl-3-ethylthio-1-oxo-1,2-dihydroisoquinoline

HRID 2049756Notes

Reaction equation

HRID 2049756 reaction equation
[CH2:1]([N:8]1[C:17](Cl)=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20]([S:22]CC)[CH3:21].[Na]>>[CH2:1]([N:8]1[C:17]([S:22][CH2:20][CH3:21])=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 203444142-Benzyl-3-chloroisoquinolin-1(2H)-oneHCID 86736943Sodium ethylsulfide

Product 1

HCID 203444222-Benzyl-3-ethylthio-1-oxo-1,2-dihydroisoquinoline

Procedure

By following the same procedure as in Example 1 using 0.5 g. of 2-benzyl-3-chloro-1-oxo-1,2-dihydroisoquinoline and 0.6 g. of an aqueous solution of 20% sodium ethylsulfide, 0.37 g. of 2-benzyl-3-ethylthio-1-oxo-1,2-dihydroisoquinoline was obtained (recrystallized from cyclohexane).

Sources & evidence

ORD record
ord-4e010d6f4897440699d8916fbed40a81
Source dataset
uspto-grants-1980_04
Patent number
US04198512

Reaction notes

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