反应详情

The mixture of 20.9 g (113 mmol) sodium trichloroacetate, 15.4 g (80 mmol) ethyl 3-phenoxy-2-propenoate and 50 ml dry 1,2-dimethoxyethane is heated under reflux for 10 hr, under nitrogen. The mixture is filtered and solvent removed. The residue is purified by chromatography on silica gel, giving ethyl 3-phenoxy-2,2-dichlorocyclopropanecarboxylate, which is then hydrolyzed, as in Example 3, to give the corresponding carboxylic acid.

1. temperatureis heated
2. temperatureunder reflux for 10 hr, under nitrogen
3. filtrationThe mixture is filtered
4. customsolvent removed
5. customThe residue is purified by chromatography on silica gel