Ethyl 3-phenoxyprop-2-enoate → Ethyl 3-phenoxy-2,2-dichlorocyclopropanecarboxylate

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Reaction Steps

The mixture of 20.9 g (113 mmol) sodium trichloroacetate, 15.4 g (80 mmol) ethyl 3-phenoxy-2-propenoate and 50 ml dry 1,2-dimethoxyethane is heated under reflux for 10 hr, under nitrogen. The mixture is filtered and solvent removed. The residue is purified by chromatography on silica gel, giving ethyl 3-phenoxy-2,2-dichlorocyclopropanecarboxylate, which is then hydrolyzed, as in Example 3, to give the corresponding carboxylic acid.

Provenance & Evidence