Diethylamine → HCID 13282756, compound

HRID 2049944Notes

Reaction equation

HRID 2049944 reaction equation
[Cl:1][C:2]1[S:3][C:4]([C:11](Cl)=[O:12])=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1.[CH2:14]([NH:16][CH2:17][CH3:18])[CH3:15]>CCOCC>[CH2:14]([N:16]([CH2:17][CH3:18])[C:11]([C:4]1[S:3][C:2]([Cl:1])=[N:6][C:5]=1[C:7]([F:10])([F:9])[F:8])=[O:12])[CH3:15]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 132827442-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride

Product 1

HCID 13282756HCID 13282756, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a well-stirred solution of 4.0 g (0.0160 mole) of the acid chloride of Example 16 in 20 ml. of ether was added dropwise 2.34 g (0.032 mole) of diethylamine in 5 ml. of ether. The insoluble salt was filtered. The ether solution was washed with water, dried and concentrated under reduced pressure. The residue was crystallized from hexane at low temperature to give 4.1 g of the desired product, m.p. 40°-41° C.

Workup

  1. filtrationThe insoluble salt was filtered
  2. washThe ether solution was washed with water
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was crystallized from hexane at low temperature

Sources & evidence

ORD record
ord-8d4ba4e94f834deaa557141a98073d0f
Source dataset
uspto-grants-1980_04
Patent number
US04199506

Reaction notes

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