反应详情

TFA (0.5 mL) was added to a solution of tert-butyl 3-({3-[(1S)-2-methoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoyl}amino)-1H-pyrazole-1-carboxylate (180 mg, 0.330 mmol) in dry DCM (3 mL) and the reaction was stirred under argon for 3 h. A further portion of TFA (0.2 mL) was then added and the reaction was stirred for 30 min before all the solvent was removed in vacuo. The residue was taken up in ethyl acetate (30 mL) and saturated aqueous sodium hydrogencarbonate (15 mL) and the residue was evaporated then re-evaporated with DCM/hexanes to produce the title compound as a colourless foam (145 mg, 100%).

1. stirringthe reaction was stirred for 30 min before all the solvent
2. customwas removed in vacuo
3. customsaturated aqueous sodium hydrogencarbonate (15 mL) and the residue was evaporated
4. customthen re-evaporated with DCM/hexanes