Hydrochloric Acid → HCID 20341786, compound

Participants

Reaction Steps

To a suspension of 40 g of 3-carboethoxymethylamino-4-dodecylcarbamoylmethoxyphenol in 500 ml of methanol was added over 20 minutes a solution of 12 g of sodium hydroxide in 100 ml of water kept at below 20° C., and the mixture was stirred for 10 minutes to obtain a perfect solution. The resulting solution was poured into 2 liters of a 5% hydrochloric acid solution, whereupon pale green crystals were separated. The crystals were recrystallized from a water-methanol mixture to obtain the title compound. The yield was 32 g, and the melting point was 122°-125° C.

Provenance & Evidence