Hydrochloric Acid → HCID 20341786, compound

HRID 2050133Notes

Reaction equation

HRID 2050133 reaction equation
[C:1]([CH2:6][NH:7][C:8]1[CH:9]=[C:10]([OH:31])[CH:11]=[CH:12][C:13]=1[O:14][CH2:15][C:16](=[O:30])[NH:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])([O:3]CC)=[O:2].[OH-].[Na+].Cl>CO.O>[C:1]([CH2:6][NH:7][C:8]1[CH:9]=[C:10]([OH:31])[CH:11]=[CH:12][C:13]=1[O:14][CH2:15][C:16](=[O:30])[NH:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])([OH:3])=[O:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20341811HCID 20341811, compound

Product 1

HCID 20341786HCID 20341786, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a suspension of 40 g of 3-carboethoxymethylamino-4-dodecylcarbamoylmethoxyphenol in 500 ml of methanol was added over 20 minutes a solution of 12 g of sodium hydroxide in 100 ml of water kept at below 20° C., and the mixture was stirred for 10 minutes to obtain a perfect solution. The resulting solution was poured into 2 liters of a 5% hydrochloric acid solution, whereupon pale green crystals were separated. The crystals were recrystallized from a water-methanol mixture to obtain the title compound. The yield was 32 g, and the melting point was 122°-125° C.

Workup

  1. customkept at below 20° C.
  2. customto obtain a perfect solution
  3. customwere separated
  4. customThe crystals were recrystallized from a water-methanol mixture

Sources & evidence

ORD record
ord-98d8ad21457642d78ce8a4f35d400f98
Source dataset
uspto-grants-1980_04
Patent number
US04200466

Reaction notes

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