反应详情

A mixture of N-cyano-N'-{2-[(thiazol-2-yl)methylthio]ethyl}-S-methylisothiourea [prepared according to the procedure described in U.S. Pat. No. 3,950,333] (4.40 g, 16.1 mmole) and propargylamine (8.8 ml) in methanol (35 ml) was stirred and heated to reflux temperature under a positive pressure of nitrogen for 16 hours. The reaction mixture was evaporated under reduced pressure, the residue dissolved in warm isopropanol, and then cooled and filtered to yield 2.26 g of product. Recrystallization from isopropanol with Darco treatment gave the title compound; mp 137.5°-139.5°.

1. customprepared
2. temperatureheated
3. temperatureto reflux temperature under a positive pressure of nitrogen for 16 hours
4. customThe reaction mixture was evaporated under reduced pressure
5. dissolutionthe residue dissolved in warm isopropanol
6. temperaturecooled
7. filtrationfiltered