反应详情

A mixture of N-cyano-N'-{2-[(2-guanidinothiazol-4-yl)methylthio]ethyl}-S-methylisothiourea [prepared according to the procedure described in South Africa Pat. No. 78/2129] (3.0 g; 9.11 mmoles) and propargylamine (6.0 ml) in methanol (15 ml) was stirred and heated at reflux temperature under a positive pressure of nitrogen for 20 hours. The reaction mixture was evaporated under reduced pressure and the residue triturated with isopropanol and filtered to give product (1.5 g). Recrystallization from nitromethane gave the title compound, mp 146°-148°.

1. customprepared
2. temperatureheated
3. temperatureat reflux temperature under a positive pressure of nitrogen for 20 hours
4. customThe reaction mixture was evaporated under reduced pressure
5. customthe residue triturated with isopropanol
6. filtrationfiltered