HCID 57111101, compound → HCID 12790406, compound

HRID 2050196Notes

Reaction equation

HRID 2050196 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH:7]=[CH:8][C:9](=[O:11])[CH3:10]>[Pd].C(OCC)(=O)C>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][CH2:8][C:9](=[O:11])[CH3:10]

Participants

4

Reactant 1

HCID 57111101HCID 57111101, compound

Product 1

HCID 12790406HCID 12790406, compoundYield 81.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 4-(1-Methyl-2-pyrryl)-but-3-en-2-one (2.98 g) and 10% palladium on charcoal (0.2 g) was hydrogenated in ethyl acetate (50 ml) at room temperature and atmospheric pressure. The catalyst was removed by filtration the solvent evaporated, and the resulting oil left overnight to solidify in a refrigerator. The long, colourless needles which formed were washed with cold 60°-80° petrol to give 4-(1-Methyl-2-pyrryl)-butan-2-one (2.46 g).

Workup

  1. customThe catalyst was removed by filtration the solvent
  2. customevaporated
  3. customThe long, colourless needles which formed
  4. washwere washed with cold 60°-80° petrol

Sources & evidence

ORD record
ord-ec07af369d774da69463bcad1bb0fc12
Source dataset
uspto-grants-1980_04
Patent number
US04200645

Reaction notes

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