反应详情

A mixture of 10 parts of N-(3-chloropropyl)-2-nitro-4-(trifluoromethyl)benzenamine, 8.11 parts of 1-(diphenylmethyl)piperazine, 8.37 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight. The reaction mixture is cooled and water is added. The organic phase is separated, washed with water, dried, filtered and evaporated. The oily residue is crystallized from 2-propanol. The product is filtered off and dried, yielding 4-(diphenylmethyl)-N-[2-nitro-4-(trifluoromethyl)phenyl]-1-piperazinepropanamine; mp. 113.7° C.

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture is cooled
3. customThe organic phase is separated
4. washwashed with water
5. customdried
6. filtrationfiltered
7. customevaporated
8. customThe oily residue is crystallized from 2-propanol
9. filtrationThe product is filtered off
10. customdried