反应详情

A mixture of 22 parts of 2,4-dichloro-α-(4-fluorophenyl)benzenemethanol and 240 parts of hydrochloric acid solution 12 N is stirred for 40 hours at room temperature. The reaction mixture is poured onto ice-water and the product is extracted with trichloromethane. The extract is washed with water, dried, filtered and evaporated. The residue is distilled, yielding 13.2 parts of 2,4-dichloro-1-[chloro-(4-fluorophenyl)methyl]benzene; bp. 146° C. at 0.15 mm. pressure.

1. additionThe reaction mixture is poured onto ice-water
2. extractionthe product is extracted with trichloromethane
3. washThe extract is washed with water
4. customdried
5. filtrationfiltered
6. customevaporated
7. distillationThe residue is distilled