1-Cyano-2,3-dimethylisothiourea → 1-Cyano-2-methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)isothiourea

HRID 2050343Notes

Reaction equation

HRID 2050343 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[CH:8][NH:9][C:10]=1[CH3:11].[C:12]([NH:14][C:15](=NC)[S:16][CH3:17])#[N:13]>>[C:12]([NH:14][C:15](=[N:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[CH:8][NH:9][C:10]=1[CH3:11])[S:16][CH3:17])#[N:13]

Participants

3

Reactant 2

HCID 1111031-Cyano-2,3-dimethylisothioureaHCID 6655684-(((2-Aminoethyl)thio)methyl)-5-methylimidazole

Product 1

HCID 1036301-Cyano-2-methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)isothiourea

Procedure

Furthermore, the final compound I can be obtained by reacting 4-[(2-aminoethyl)-thiomethyl]-5-methyl imidazole with N-cyano-N',S-dimethylisothiourea or with dimethylcyanodithioimido carbonate to form N-cyano-N'-{2-[(5-methylimidazole-4-yl)-methylthio]-ethyl}-S-methylisothiourea, which reacts with methylamine, thus yielding the final compound I.

Sources & evidence

ORD record
ord-283a9fab509d42b290276d309c3385d8
Source dataset
uspto-grants-1980_04
Patent number
US04200761

Reaction notes

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