Propargylamine → HCID 178457315, compound

HRID 2050362Notes

Reaction equation

HRID 2050362 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[CH2:7][S:8][CH2:9][CH2:10][NH2:11].[C:12]([CH:14]=[C:15](OCC)[NH:16][C:17]#[C:18][CH3:19])#[N:13].C(N)C#C.C(C=C(OC)OC)#N>>[C:12]([CH:14]=[C:15]([NH:16][CH2:17][C:18]#[CH:19])[NH:11][CH2:10][CH2:9][S:8][CH2:7][C:6]1[NH:5][CH:4]=[N:3][C:2]=1[CH3:1])#[N:13]

Participants

5

Reactant 4

HCID 239041PropargylamineHCID 226227003,3-Dimethoxyprop-2-enenitrileHCID 867369511-Cyano-2-ethoxy-2-propynylaminoethyleneHCID 178433288HCID 178433288, compound

Product 1

HCID 178457315HCID 178457315, compound

Procedure

When 2-[(4-methyl-1H-imidazol-5-yl)methylthio] ethylamine [prepared according to the procedure described in U.S. Pat. No. 3,950,353] is reacted with 1-cyano-2-ethoxy-2-propynylaminoethylene [prepared by the reaction of propargylamine with 1-cyano-2,2-bis(methoxy)ethylene, itself prepared by the procedure described in J. Am. Chem. Soc., 71, 47 (1949)], the title product is produced.

Workup

  1. customprepared by the procedure

Sources & evidence

ORD record
ord-53f27c61c0a64272aac4102ea3e62a7a
Source dataset
uspto-grants-1980_04
Patent number
US04200760

Reaction notes

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