HCID 86734330, compound → cis-2-Aminomethyl-4-oxo-3-phenoxyacetylaminoazetidine

HRID 2050392Notes

Reaction equation

HRID 2050392 reaction equation
[N:1]([CH2:4][C@H:5]1[C@@H:8]([NH:9][C:10](=[O:19])[CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7](=[O:20])[NH:6]1)=[N+]=[N-]>[Pd].C(O)C>[NH2:1][CH2:4][C@H:5]1[C@@H:8]([NH:9][C:10](=[O:19])[CH2:11][O:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:7](=[O:20])[NH:6]1

Participants

4

Reactant 1

HCID 86734330HCID 86734330, compound

Product 1

HCID 70593118cis-2-Aminomethyl-4-oxo-3-phenoxyacetylaminoazetidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 0.499 g (1.81 mmole) of cis-2-azidomethyl-4-oxo-3-phenoxyacetylaminoazetidine and 0.189 g of 10% palladium on carbon in 25 ml of absolute ethanol was hydrogenated at atmospheric pressure and at 40° for 1 hour. The solution was filtered through celite and the solvent was removed in vacuo to afford the title compound as a colorless gum.

Workup

  1. filtrationThe solution was filtered through celite
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-86f832a4941d43b1a9d4d2c1e18e7a04
Source dataset
uspto-grants-1980_04
Patent number
US04200572

Reaction notes

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