Sodium Phosphate, Dibasic → Methyl cis-3-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)-4-oxoazetidine-2-carboxylate

HRID 2050396Notes

Reaction equation

HRID 2050396 reaction equation
COC1C=C(OC)C=CC=1C[N:6]1[C:9](=[O:10])[C@H:8]([N:11]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:14]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[O:13][C:12]2=[O:28])[C@@H:7]1[C:29]([O:31][CH3:32])=[O:30].S(OOS([O-])(=O)=O)([O-])(=O)=O.[K+].[K+].P([O-])([O-])(O)=O.[Na+].[Na+]>>[C:16]1([C:15]2[N:11]([C@H:8]3[C:9](=[O:10])[NH:6][C@H:7]3[C:29]([O:31][CH3:32])=[O:30])[C:12](=[O:28])[O:13][C:14]=2[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 24203Sodium Phosphate, DibasicHCID 24412Potassium PersulfateHCID 70576596Methyl cis-1-(2,4-dimethoxybenzyl)-3-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)-4-oxoazetidine-2-carboxylate

Product 1

HCID 70577957Methyl cis-3-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)-4-oxoazetidine-2-carboxylate

Procedure

Methyl cis-1-(2,4-dimethoxybenzyl)-3-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)-4-oxoazetidine-2-carboxylate is treated with potassium persulfate and sodium monohydrogen phosphate as described in Preparation 5 to give methyl cis-3-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)-4-oxoazetidine-2-carboxylate.

Workup

  1. customas described in Preparation 5

Sources & evidence

ORD record
ord-5b9941f92a174faabdaebb54a3b7257a
Source dataset
uspto-grants-1980_04
Patent number
US04200572

Reaction notes

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