Acetic Acid → HCID 12762854, compound

HRID 2050409Notes

Reaction equation

HRID 2050409 reaction equation
[CH3:1][S:2][C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[N:13]=[C:12]([C:14](OC)=[O:15])[CH:11]=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.CC(C[AlH]CC(C)C)C.C(O)(=O)C.O>C1(C)C=CC=CC=1.CCCCCC>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([O:7][C:8]2[N:13]=[C:12]([CH:14]=[O:15])[CH:11]=[CH:10][CH:9]=2)=[CH:18][CH:19]=1

Participants

7

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 14487Diisobutylaluminum hydride2×HCID 14998256HCID 14998256, compound

Product 1

HCID 12762854HCID 12762854, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8058HexaneSolvent2×

Conditions

Temperature
70 °C

Procedure

A solution of 38.7 g (0.141 mol) of methyl 6-(4-(methylthio)phenoxy)picolinate in 250 mL of toluene was cooled to a minus 70° C. in a dry ice-acetone bath. To the thus prepared slurry was added dropwise 285 mL of 1 Molar DIBAL-H in hexane over 1.5 hours. The solution was stirred at minus 70° C. for 20 minutes and an additional 20 mL of 1 Molar DIBAL-H in hexane was added. After 15 minutes, a solution of 187.5 mL of diether ether, 62.5 mL of glacial acetic acid and 15 mL of water was added dropwise over 1.5 hours at minus 65° C. with a white solid forming. The thus formed slurry was allowed to stir at ambient temperature overnight and the white solid was collected by filtration and washed with diether ether. The filtrate was washed thrice with 250 mL portions of water followed by washing with 250 mL of a 10 percent sodium bicarbonate solution and then with 250 mL of water. The organic layer was then dried over sodium sulfate and the solvent removed in vacuo leaving 32.4 g (94.1 percent of theoretical) of the above named compound, a white crystalline solid, melting at 60° -63° C.; 1H NMR (CDCl3) δ2.40 (s, 3H, CH3S--), 6.9-7.9 (m, 7H, ArH),9.75 (s, 1H, --CH=O).

Workup

  1. waitAfter 15 minutes
  2. customforming
  3. stirringto stir at ambient temperature overnight
  4. filtrationthe white solid was collected by filtration
  5. washwashed with diether ether
  6. washThe filtrate was washed thrice with 250 mL portions of water
  7. washby washing with 250 mL of a 10 percent sodium bicarbonate solution
  8. dry with materialThe organic layer was then dried over sodium sulfate
  9. customthe solvent removed in vacuo
  10. customleaving 32.4 g (94.1 percent of theoretical) of the

Sources & evidence

ORD record
ord-12c5ed45bca44750a66f60b59c47030a
Source dataset
uspto-grants-1991_05
Patent number
US05013352

Reaction notes

Loading…