反应详情

Sodium metal (2.3 g; 0.1 mole) is dissolved in methanol (160 g; 5 moles). The solution is heated to reflux and treated dropwise over 2 hours with isooctyl glycidyl ether (186 g; 1 mole). After complete addition, the reaction mixture is maintained under reflux conditions for a further 6 hours. After cooling to ambient temperature, the reaction mixture is treated with acetic acid (5.8 g; 0.1 mole) and then the excess solvent is removed under vacuum. The oily residue is treated with water (250 ml) and then extracted with ether (250 ml). The ether extract is dried over MgSO4, filtered and evaporated. The residue is distilled under vacuum to yield 1-isooctyl-3-methyl glycerol, as a colourless oil, bp 75°-80° C./0.07 mbar, yield 145.6 g (67%).

1. temperatureThe solution is heated
2. temperatureto reflux
3. additionAfter complete addition
4. temperaturethe reaction mixture is maintained under reflux conditions for a further 6 hours
5. customthe excess solvent is removed under vacuum
6. additionThe oily residue is treated with water (250 ml)
7. extractionextracted with ether (250 ml)
8. extractionThe ether extract
9. dry with materialis dried over MgSO4
10. filtrationfiltered
11. customevaporated
12. distillationThe residue is distilled under vacuum