Sodium cyanoborohydride → HCID 136054883, compound

Participants

Reaction Steps

A 136.3 g amount of 7-(3-fluorophenyl)-pyrazolo(1,5-a)pyrimidine-3-carboxamide (prepared as described in Example 7) in one liter of glacial acetic acid is stirred at room temperature, then 83.6 g of sodium cyanoborohydride is added portionwise under nitrogen. The mixture is stirred for 16 hours, then the precipitated crystals are collected by filtration and triturated with saturated sodium bicarbonate until pH 7-8 is achieved. The crystals are washed with water and dried in vacuo to give 63.0 g of the product as cream colored crystals, mp 122-125° C.

Provenance & Evidence