Sodium cyanoborohydride → HCID 136054883, compound

HRID 2050506Notes

Reaction equation

HRID 2050506 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17]([NH2:19])=[O:18])=[C:12]3[N:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C([BH3-])#N.[Na+]>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17]([NH2:19])=[O:18])=[C:12]3[NH:11][CH2:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 5003444Sodium cyanoborohydrideHCID 14501865HCID 14501865, compound

Product 1

HCID 136054883HCID 136054883, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A 136.3 g amount of 7-(3-fluorophenyl)-pyrazolo(1,5-a)pyrimidine-3-carboxamide (prepared as described in Example 7) in one liter of glacial acetic acid is stirred at room temperature, then 83.6 g of sodium cyanoborohydride is added portionwise under nitrogen. The mixture is stirred for 16 hours, then the precipitated crystals are collected by filtration and triturated with saturated sodium bicarbonate until pH 7-8 is achieved. The crystals are washed with water and dried in vacuo to give 63.0 g of the product as cream colored crystals, mp 122-125° C.

Workup

  1. filtrationthe precipitated crystals are collected by filtration
  2. customtriturated with saturated sodium bicarbonate until pH 7-8
  3. washThe crystals are washed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-744312b3c03346f198ed2827ca2f7bb8
Source dataset
uspto-grants-1991_05
Patent number
US05013737

Reaction notes

Loading…