1,1'-Carbonyldiimidazole → 7,8-Dihydro-8-(3-(trifluoromethyl)phenyl)-3H,6H-1,4,5a,8a-tetraazaacenaphthylene-3,5(4H)-dione

Participants

Reaction Steps

To a 3.0 g portion of 4,5,6,7-tetrahydro-7-(3-(trifluoromethyl)phenyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide (Example 13) suspended in 40 ml of dry tetrahydrofuran is added portionwise under nitrogen 8.0 g of 1,1'-carbonyldiimidazole and 60 ml of dry tetrahydrofuran. The reaction mixture is heated at reflux for 96 hours, and then is cooled to give a white precipitate which is collected by filtration. The precipitate is treated with 10 ml of water, filtered and dried to give 1.05 g of the desired product as a white solid, mp 297-300° C.

Provenance & Evidence