反应详情

To a 3.0 g portion of 4,5,6,7-tetrahydro-7-(3-(trifluoromethyl)phenyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide (Example 13) suspended in 40 ml of dry tetrahydrofuran is added portionwise under nitrogen 8.0 g of 1,1'-carbonyldiimidazole and 60 ml of dry tetrahydrofuran. The reaction mixture is heated at reflux for 96 hours, and then is cooled to give a white precipitate which is collected by filtration. The precipitate is treated with 10 ml of water, filtered and dried to give 1.05 g of the desired product as a white solid, mp 297-300° C.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 96 hours
3. temperatureis cooled
4. customto give a white precipitate which
5. filtrationis collected by filtration
6. additionThe precipitate is treated with 10 ml of water
7. filtrationfiltered
8. customdried