Hydrochloric Acid → HCID 10037816, compound

HRID 2050728Notes

Reaction equation

HRID 2050728 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:10]([F:15])([F:14])[CH2:11][CH2:12][CH3:13])(=[O:9])[O:6]CC.[ClH:16]>>[ClH:16].[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:10]([F:15])([F:14])[CH2:11][CH2:12][CH3:13])(=[O:6])[OH:9]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10263800HCID 10263800, compound

Product 1

HCID 10037816HCID 10037816, compound

Conditions

Temperature
80 °C

Procedure

A mixture of 1.4 g (5.8 mMol) of ethyl 3-aminopropyl(1,1difluorobutyl)phosphinate and 15 ml of 12 M hydrochloric acid is stirred for 8 hours at 80° C. The reaction mixture is evaporated to dryness and the residue is recrystallized from ethanol/ether giving 3-aminopropyl(1,1-difluorobutyl)phosphinic acid hydrochloride, m.p. 149-151° C.

Workup

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue is recrystallized from ethanol/ether

Sources & evidence

ORD record
ord-de05a1eaa0f04a06bd605abcca21f572
Source dataset
uspto-grants-1991_05
Patent number
US05013863

Reaction notes

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