Ethanol → HCID 19821140, compound

HRID 2050759Notes

Reaction equation

HRID 2050759 reaction equation
C([O:9][C:10]1[CH:15]=[C:14]([NH:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:13]([O:25][CH3:26])=[CH:12][C:11]=1[CH3:27])(=O)C1C=CC=CC=1.[OH-].[Na+].C(O)C>Cl>[CH3:27][C:11]1[CH:12]=[C:13]([O:25][CH3:26])[C:14]([NH:16][C:17](=[O:24])[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:15][C:10]=1[OH:9]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 19821153HCID 19821153, compound

Product 1

HCID 19821140HCID 19821140, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

3 g (8.3 mmol) of 2-methyl-4-methoxy-5-benzoylaminophenyl benzoate was added into the mixture of 50 ml of sodium hydroxide and 50 ml of ethanol and the solution was heated at 100° C. under reflux for 2.5 hours. 40 ml of IN hydrochloric acid was added to the reaction mixture and precipitates were filtered, washed with water and recrystallized from ethanol to give 1.2 g (4.6 mmol) of 2-methyl-4-methoxy-5-benzoylaminophenol in the form of pale yellow plate-like crystals. The yield was 78%.

Workup

  1. temperatureunder reflux for 2.5 hours
  2. customprecipitates
  3. filtrationwere filtered
  4. washwashed with water
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-207878e2540f4031be8e07442543dc93
Source dataset
uspto-grants-1991_05
Patent number
US05015260

Reaction notes

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