2-(Chloromethyl)-6-methylpyridine → 1,3-Benzoxazole-2-carbaldehyde

HRID 2050779Notes

Reaction equation

HRID 2050779 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10](OC)=[O:11].ClCC1C=CC=C(C)N=1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]=[O:11]

Participants

3

Reactant 2

HCID 765462-(Chloromethyl)-6-methylpyridineHCID 13353743Methyl 1,3-benzoxazole-2-carboxylate

Product 1

HCID 44833931,3-Benzoxazole-2-carbaldehydeYield 35%

Procedure

The title compound was prepared from methyl benzoxazole-2-carboxylate by the method of part (ii), above, on a 0.041 molar scale; yield 35% as a yellow oil. 1H-NMR(CDCl3)ppm(delta): 7.3-8.1 (m, 4H), 10.0 (s, 1H).

Sources & evidence

ORD record
ord-54a6e228780d4e499b9a7031251577d4
Source dataset
uspto-grants-1991_05
Patent number
US05015473

Reaction notes

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