反应详情

The operation is carried out as in Example 1 using 1.75 g of 3-methoxy methylidene quinuclidine, 3.8 cm3 of perchloric acid and 1.22 g of O-2-propynylhydroxylamine hydrochloride (U.S. Pat. No. 3,398,180 (1968)). After the ethyl ether has been evaporated off, the residue is chromatographed on silica (eluant: chloroform-methanol 7-3) then distilled at 190° C. under 0.05 mbar and 1.35 g of expected product is obtained.

1. customAfter the ethyl ether has been evaporated off
2. customthe residue is chromatographed on silica (eluant: chloroform-methanol 7-3)
3. distillationthen distilled at 190° C. under 0.05 mbar