Water → HCID 178492972, compound

HRID 2050907Notes

Reaction equation

HRID 2050907 reaction equation
[CH3:1][O:2][C:3]1[C:4]([C:9]([OH:11])=[S:10])=[C:5]([CH3:8])[S:6][CH:7]=1.[Cl:12]N1C(=O)CCC1=O.O>C(Cl)(Cl)Cl.C(O)(=O)C>[Cl:12][C:7]1[S:6][C:5]([CH3:8])=[C:4]([C:9]([OH:11])=[S:10])[C:3]=1[O:2][CH3:1]

Participants

5

Reactant 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 178493949HCID 178493949, compound

Product 1

HCID 178492972HCID 178492972, compound

Reagents, catalysts & solvents 1

HCID 21584526Acetic acid chloroformSolvent

Procedure

Equimolecular amounts of the thiophene (d) above and N-chlorosuccinimide were dissolved in 1/1 chloroform/acetic acid mixture. The mixture was stirred for two hours and then poured into water. The organic layer was washed with 10% aqueous sodium hydroxide, dried over sodium sulphate and the solvent evaporated. The carboxylic acid was purified by recrystallisation from ethanol, m.p. 193°-194° C.

Workup

  1. washThe organic layer was washed with 10% aqueous sodium hydroxide
  2. dry with materialdried over sodium sulphate
  3. customthe solvent evaporated
  4. customThe carboxylic acid was purified by recrystallisation from ethanol, m.p. 193°-194° C.

Sources & evidence

ORD record
ord-93487e119c8f482eadf6a1943ec07b9f
Source dataset
uspto-grants-1991_05
Patent number
US05015656

Reaction notes

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