Sulfuric Acid → HCID 57324703, compound

HRID 2050915Notes

Reaction equation

HRID 2050915 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][CH2:7][C:8]([OH:10])=[O:9].S(=O)(=O)(O)O.[CH2:16]=[C:17]([CH3:19])[CH3:18].[OH-].[Na+]>CCOCC.C(COC)OC>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][CH2:7][C:8]([O:10][C:17]([CH3:19])([CH3:18])[CH3:16])=[O:9]

Participants

7

Reactant 4

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 14798Sodium HydroxideHCID 21071957HCID 21071957, compound

Product 1

HCID 57324703HCID 57324703, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 12.6 g of 2-thienylaminoacetic acid, 300 ml of dimethoxyethane, 15 ml of sulphuric acid and 100 ml of isobutene is stirred at room temperature in an autoclave for 5 h and poured into a mixture composed of 800 ml of ether and 800 ml of 1N sodium hydroxide solution. The ethereal phase is separated off, and the aqueous phase is extracted twice more by shaking with 200 ml of ether each time. After drying of the ether phases over MgSO4 and evaporation of the solvent there remains a yellowish oily residue.

Workup

  1. additionpoured into a mixture
  2. customThe ethereal phase is separated off
  3. extractionthe aqueous phase is extracted twice more
  4. stirringby shaking with 200 ml of ether each time
  5. dry with materialAfter drying of the ether phases over MgSO4 and evaporation of the solvent

Sources & evidence

ORD record
ord-e6f9c95db88c4f959f103f0dcb11a251
Source dataset
uspto-grants-1991_05
Patent number
US05015659

Reaction notes

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