Ethanol → HCID 73454225, compound

HRID 2050920Notes

Reaction equation

HRID 2050920 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=O)[C:7]([NH2:9])=[O:8].C(O)C.Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+]>O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:15][OH:16])[C:7]([NH2:9])=[O:8]

Participants

6

Reactant 4

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 14774041HCID 14774041, compound

Product 1

HCID 73454225HCID 73454225, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
40 °C

Procedure

A mixture of 15.5 g of 2-thienylglyoxylamide, 75 ml of water, 75 ml of ethanol, 10.4 g of hydroxylamine hydrochloride and 24.6 g of sodium acetate is stirred at 40° C. for 5 h, the volatile fractions are stripped off in vacuo, and the residue is taken up in water. The product is extracted with ethyl acetate, and the organic phase is dried and concentrated. The residue is recrystallized from a little ethyl acetate.

Workup

  1. extractionThe product is extracted with ethyl acetate
  2. customthe organic phase is dried
  3. concentrationconcentrated
  4. customThe residue is recrystallized from a little ethyl acetate

Sources & evidence

ORD record
ord-7094351d5a0a4e148b203add35536602
Source dataset
uspto-grants-1991_05
Patent number
US05015659

Reaction notes

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