Acetophenone → HCID 14984870, compound

HRID 2051051Notes

Reaction equation

HRID 2051051 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C[C:11]1[CH:16]=[CH:15][CH:14]=[C:13](C)[C:12]=1[C:18]([O:20]C)=O.[CH3:22][O-].[Na+]>C1(C)C(C)=CC=CC=1>[C:1]([CH2:2][C:18](=[O:20])[C:12]1[CH:11]=[CH:16][CH:15]=[C:14]([CH3:22])[CH:13]=1)(=[O:3])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 7410AcetophenoneHCID 519028Methyl 2,6-dimethylbenzoateHCID 10942334Sodium Methoxide

Product 1

HCID 14984870HCID 14984870, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Acetophenone (30 grams; 0.25 mol) methyl m-methyltoluate (136 grams; 1.0 mol), xylene (300 ml) and sodium methoxide (17.3 grams; 0.3 mol) were placed into a four-necked round bottom one liter flask equipped as in Example 1. The mixture was heated with stirring to 135°-140° C. and maintained there for 6 hours under a blanket of nitrogen. The procedure set forth in Example 1 was used to recover the desired product, benzoyl m-methylbenzoylmethane (48 grams; 90% weight percent yield).

Workup

  1. customequipped as in Example 1
  2. temperatureThe mixture was heated
  3. temperaturemaintained there for 6 hours under a blanket of nitrogen
  4. customto recover the desired product, benzoyl m-methylbenzoylmethane (48 grams; 90% weight percent yield)

Sources & evidence

ORD record
ord-21977770017644fda8ed57708ac15e22
Source dataset
uspto-grants-1991_05
Patent number
US05015777

Reaction notes

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