反应详情

A solution of 13.0 g of 3-amino-6-chloropyridazine, 15.2 g of bromoacetone in 200 ml of propanol is heated under reflux for 3 hours. After cooling, the precipitated crystals are collected by filtration and dissolved in 100 ml of water. The solution is neutralized with potassium carbonate and the precipitated crystals are collected by filtration. Upon recrystallization from ethanol, it affords 8.2 g of the title compound having mp. 131° C.

1. temperatureunder reflux for 3 hours
2. temperatureAfter cooling
3. filtrationthe precipitated crystals are collected by filtration
4. dissolutiondissolved in 100 ml of water
5. filtrationthe precipitated crystals are collected by filtration
6. customUpon recrystallization from ethanol, it